Article

Muller’s ratchet as a mechanism of frailty and multimorbidity

2018-10-10

Abstract excerpt

Mutation accumulation has been proposed as a cause of senescence. In this process, both constitutional and recurrent mutations accumulate gradually and differentially among differentiating cells, tissues and organs, in relation to stage and age, analogous to Muller’s ratchet in asexually reproducing organisms. Latent and cascading deleterious effects of mutations might initiate steady “accumulation of deficits” in...

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Literature Corpus work: 5951786f-ce09-5b2e-90ed-648457a2e905
DOI: 10.1101/439877

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