Article
Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging.
Cell - 9 Jul 2020
Vijg Jan, Dong Xiao
Abstract excerpt
Age-related accumulation of postzygotic DNA mutations results in tissue genetic heterogeneity known as somatic mosaicism. Although implicated in aging as early as the 1950s, somatic mutations in normal tissue have been difficult to study because of their low allele fractions. With the recent emergence of cost-effective high-throughput sequencing down to the single-cell level, enormous progress has been made in...
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