Article

Inverse Game Theory Characterizes Frequency-Dependent Selection Driven by Karyotypic Diversity in Triple Negative Breast Cancer

2025-03-25

Abstract excerpt

Chromosomal instability (CIN), characterized by pervasive copy number alterations (CNAs), significantly contributes to cancer progression and therapeutic resistance. CNAs drive intratumoral genetic heterogeneity, creating distinct subpopulations whose interactions shape tumor evolution through frequency-dependent selection. Here, we introduce, ECO-K (Ecological-Karyotypes), an inverse game theory framework that in...

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Literature Corpus work: 23d05b53-2c11-549b-858e-7d500311f25c
DOI: 10.1101/2025.03.23.644809

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