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Multi-omics analysis reveals the role of tumor-infiltrating CD4+CCR7+ T cells in EGFR antibody resistance and prognosis of hepatocellular carcinoma

2025-08-21

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<title>Abstract</title> <p> <bold>Background</bold> Despite the crucial involvement of the EGFR pathway in hepatocellular carcinoma (HCC), the clinical efficacy of EGFR antibodies in HCC remains uncertain. While existing evidence suggests that immune dysfunction and tumor microenvironment alterations may contribute to treatment resistance, the precise mechanisms underlying this phenomenon in HCC warrant further...

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Literature Corpus work
c7062f03-db0e-51a9-8976-60a53161fab2
DOI
10.21203/rs.3.rs-7189781/v1
Open publication

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Multi-omics analysis reveals the role of tumor-infiltrating CD4+CCR7+ T cells in EGFR antibody resistance and prognosis of hepatocellular carcinomaDOI 10.21203/rs.3.rs-7189781/v1
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