Article

Integrated Single-Cell and Spatial Transcriptomics Identifies an RBM8A/HDAC9/p16 Axis Driving Early Recurrence in Hepatocellular Carcinoma

2026-07-08

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Surgical resection remains the primary curative therapy for early-stage hepatocellular carcinoma, yet high early recurrence driven by profound tumor heterogeneity severely limits long-term patient survival. Identifying specific malignant subpopulations and dissecting their core regulatory mechanisms represents a critical unmet clinical challenge. <bold>Method...

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Literature Corpus work: f7dfd868-7899-5908-8e4d-c385dab02636
DOI: 10.21203/rs.3.rs-10134809/v1

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