Article
Optical Control of Tumor Induction in the Zebrafish.
Scientific reports - 23 Aug 2017
Feng Zhiping, Nam Suzy, Hamouri Fatima, Aujard Isabelle, Ducos Bertrand, Vriz Sophie, Volovitch Michel, Jullien Ludovic, Lin Shuo, Weiss Shimon, Bensimon David
Abstract excerpt
The zebrafish has become an increasingly popular and valuable cancer model over the past few decades. While most zebrafish cancer models are generated by expressing mammalian oncogenes under tissue-specific promoters, here we describe a method that allows for the precise optical control of oncogene expression in live zebrafish. We utilize this technique to transiently or constitutively activate a typical human...
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