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Article

Multi-organ Mapping of Cancer Risk.

Cell - 25 Aug 2016

Zhu Liqin, Finkelstein David, Gao Culian, Shi Lei, Wang Yongdong, López-Terrada Dolores, Wang Kasper, Utley Sarah, Pounds Stanley, Neale Geoffrey, Ellison David, Onar-Thomas Arzu, Gilbertson Richard James

Abstract excerpt

Cancers are distributed unevenly across the body, but the importance of cell intrinsic factors such as stem cell function in determining organ cancer risk is unknown. Therefore, we used Cre-recombination of conditional lineage tracing, oncogene, and tumor suppressor alleles to define populations of stem and non-stem cells in mouse organs and test their life-long susceptibility to tumorigenesis. We show that tumor...

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Identifiers

PMID: 27565343
DOI: 10.1016/j.cell.2016.07.045
PMCID: PMC5067024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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