Article

Convergence for Inactivation of TGFβ Signaling Is a Common Feature of Advanced Pancreatic Cancer

2024-01-30

Abstract excerpt

We performed WES of 250 unique tumor tissues from 30 multiregion sampled pancreatic cancer research autopsies from patients diagnosed with advanced stage disease. We find that most genetic alterations in PDAC occur in a subclonal manner, and some genes occurred in a subclonal manner exclusively. Convergent evolution within the TGFβ pathway was also identified as a common feature of advanced stage disease, with SMA...

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Literature Corpus work: 2355deaa-d490-542a-a53e-ca76e22f8d56
DOI: 10.1101/2024.01.30.24301554

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