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Article

Pathway-Specific Genomic Alterations in Pancreatic Cancer Across Populations at Risk.

International journal of molecular sciences - 8 Aug 2025

Monge Cecilia, Waldrup Brigette, Carranza Francisco G, Manjarrez Sophia, Velazquez-Villarreal Enrique

Abstract excerpt

Pancreatic cancer (PC) is a highly aggressive malignancy with increasing incidence and poor survival. Hispanic/Latino (H/L) patients, despite having a lower overall incidence than Non-Hispanic White (NHW) patients, are often diagnosed younger and at more advanced stages, leading to worse outcomes. The molecular mechanisms underlying these disparities remain unclear. This study characterizes mutations in key...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40869017
DOI: 10.3390/ijms26167695
PMCID: PMC12386847

Genes

PC
ALK
CTNNB1
ERBB4
SMAD2
SMAD4
TP53
HRAS
RIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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