ctDNA whole exome sequencing in pancreatic ductal adenocarcinoma unveils organ-dependent metastatic mechanisms and identifies actionable alterations in fast progressing patients.

doi:10.1016/j.trsl.2024.05.003

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Article

ctDNA whole exome sequencing in pancreatic ductal adenocarcinoma unveils organ-dependent metastatic mechanisms and identifies actionable alterations in fast progressing patients.

Translational research : the journal of laboratory and clinical medicine - 1 Sept 2024

Huerta Marisol, Martín-Arana Jorge, Gimeno-Valiente Francisco, Carbonell-Asins Juan Antonio, García-Micó Blanca, Martínez-Castedo Belén, Robledo-Yagüe Fabián, Camblor Daniel G, Fleitas Tania, García Bartolomé Miguel, Alfaro-Cervelló Clara, Garcés-Albir Marina, Dorcaratto Dimitri, Muñoz-Forner Elena, Seguí Víctor, Mora-Oliver Isabel, Gambardella Valentina, Roselló Susana, Sabater Luis, Roda Desamparados, Cervantes Andrés, Tarazona Noelia

Abstract excerpt

Understanding progression mechanisms and developing new targeted therapies is imperative in pancreatic ductal adenocarcinoma (PDAC). In this study, 80 metastatic PDAC patients were prospectively recruited and divided into discovery (n=37) and validation (n=43) cohorts. Tumor and plasma samples taken at diagnosis were pair analyzed using whole exome sequencing (WES) in patients belonging to the discovery cohort...

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PMID: 38782356
DOI: 10.1016/j.trsl.2024.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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