Article
Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy.
Expert opinion on therapeutic targets - 1 Jan 2016
Sahin Ibrahim H, Iacobuzio-Donahue Christine A, O'Reilly Eileen M
Abstract excerpt
INTRODUCTION: Pancreatic adenocarcinoma remains one of the most clinically challenging cancers despite an in-depth characterization of the molecular underpinnings and biology of this disease. Recent whole-genome-wide studies have elucidated the diverse and complex genetic alterations which generate a unique oncogenic signature for an individual pancreatic cancer patient and which may explain diverse disease...
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