Article
Discovering causal signaling pathways through gene-expression patterns.
Nucleic acids research - 1 Jul 2010
Parikh Jignesh R, Klinger Bertram, Xia Yu, Marto Jarrod A, Blüthgen Nils
Abstract excerpt
High-throughput gene-expression studies result in lists of differentially expressed genes. Most current meta-analyses of these gene lists include searching for significant membership of the translated proteins in various signaling pathways. However, such membership enrichment algorithms do not provide insight into which pathways caused the genes to be differentially expressed in the first place. Here, we present...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.