Article

Cooperativity between Ras pathway mutations in colonic tumorigenesis

2025-09-06

Abstract excerpt

The Kirsten rat sarcoma ( KRAS ) gene is the most frequently mutated oncogene in colorectal cancer (CRC). We previously characterized two activating alleles of KRAS , A59T and A59E, that show impaired BRAF dimerization. These alleles of KRAS are enriched in CRC tumors with genetic alterations in genes that regulate MAPK signaling (e.g. EGFR, NF1). Using a new conditional mouse model of K-Ras (LSL-K-Ras A59E) we...

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Literature Corpus work: 232b9dbd-2d4e-5d6f-b9b7-01351d0bb6d6
DOI: 10.1101/2025.09.05.673994

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