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Article

Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF.

Oncogene - 10 Mar 2016

Cisowski J, Sayin V I, Liu M, Karlsson C, Bergo M O

Abstract excerpt

KRAS and BRAF are among the most commonly mutated oncogenes in human cancer that contribute to tumorigenesis in both distinct and overlapping tissues. However, KRAS and BRAF mutations are mutually exclusive; they never occur in the same tumor cell. The reason for the mutual exclusivity is unknown, but there are several possibilities. The two mutations could be functionally redundant and not create a selective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 26028035
DOI: 10.1038/onc.2015.186

Genes

BRAF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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