Article

Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8⁺ T-cell clonal dominance in head and neck cancer

2026-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Concomitant chemoradiotherapy (CRT) is a standard-of-care for unresectable locally-advanced head and neck squamous cell carcinoma (LA-SCCHN), but its immune effects, particularly compared to radiotherapy (RT) alone, remain unclear. Using syngeneic murine models, we integrated Nr4a3-Tocky reporter analysis with single-cell transcriptomics and T-cell receptor clonotyping comprehensively to profile...

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Literature Corpus work: 231d714a-cdd4-5d04-a26f-6672df946ed1
DOI: 10.64898/2026.03.10.710795

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