Article

TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through a transcriptional repression mechanism

2022-01-11

Abstract excerpt

Vocalization is an essential medium for sexual and social signaling in birds and mammals. Periaqueductal gray (PAG) a conserved midbrain structure is believed to be responsible for innate vocalizations, but its molecular regulation remains largely unknown. Here, through a mouse forward genetic screening we identified one of the key Wnt/ β-catenin effectors TCF7L2/TCF4 controls ultrasonic vocalization (USV) product...

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Literature Corpus work: 1b6e69cc-5a22-58be-bf00-3c5646ced8b9
DOI: 10.1101/2022.01.10.475593

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