Article
A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation.
Translational psychiatry - 3 Sept 2013
Martin P-M, Yang X, Robin N, Lam E, Rabinowitz J S, Erdman C A, Quinn J, Weiss L A, Hamilton S P, Kwok P-Y, Moon R T, Cheyette B N R
Abstract excerpt
Wnt signaling, which encompasses multiple biochemical pathways that regulate neural development downstream of extracellular Wnt glycoprotein ligands, has been suggested to contribute to major psychiatric disorders including autism spectrum disorders (ASD). We used next-generation sequencing and Sequenom genotyping technologies to resequence 10 Wnt signaling pathway genes in 198 ASD patients and 240 matched...
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