Defective ventral neurogenesis due to midfetal Chd8 mutation drives autistic-like behavior in mice.

doi:10.1038/s41467-026-73416-2

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Article

Defective ventral neurogenesis due to midfetal Chd8 mutation drives autistic-like behavior in mice.

Nature communications - 27 May 2026

Nitahara Kenta, Kawamura Atsuki, Tashiro Ayumu, Iwasaki Tomoya, Horike Shin-Ichi, Terakawa Jumpei, Daikoku Takiko, Higashi Koichi, Kurokawa Ken, Kato Kiyoko, Nishiyama Masaaki

Abstract excerpt

Autism spectrum disorder (ASD) is a common neurodevelopmental condition characterized by behavioral abnormalities. Although mouse models have been widely adopted to recapitulate the pathology of ASD, the identification of specific neural abnormalities responsible for autistic-like behavior has remained challenging. Here we provide insight into this causal relation by identifying the critical period and cell type...

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PMID: 42203765
DOI: 10.1038/s41467-026-73416-2
PMCID: PMC13216556

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