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Article

TRPML3 and hearing loss in the varitint-waddler mouse.

Biochimica et biophysica acta - 1 Aug 2007

Atiba-Davies Margaret, Noben-Trauth Konrad

Abstract excerpt

TRPML3 (also known as mucolipin-3, MCOLN3) belongs to the small family of TRPML ion channel proteins. The mammalian Trpml3 gene encodes a protein of 553 amino acids with short amino and carboxy termini and a transient receptor potential motif spanning from the third to the sixth trans membrane do...

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Source

Identifiers

PMID: 17329082
DOI: 10.1016/j.bbadis.2007.01.007

Genes

MCOLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17329082-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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TRPML3 and hearing loss in the varitint-waddler mouse.PMID 17329082Read ↗

TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice.Semantic proximity Read ↗

The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence.Semantic proximity Read ↗

The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.Semantic proximity Read ↗

Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.Semantic proximity Read ↗

Expression of transient receptor potential channel mucolipin (TRPML) and polycystine (TRPP) in the mouse inner ear.Semantic proximity Read ↗

Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice.Semantic proximity Read ↗

The TRPML3 channel: from gene to function.Semantic proximity Read ↗

Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype.Semantic proximity Read ↗

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