Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse.

doi:10.1111/j.1600-0749.1994.tb00015.x

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Article

Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse.

Pigment cell research - 1 Feb 1994

Cable J, Huszar D, Jaenisch R, Steel K P

Abstract excerpt

The W locus encodes a tyrosine kinase receptor, c-kit, which affects survival of melanoblasts from the neural crest. The primary cochlear defect in Viable Dominant Spotting (Wv/Wv) mutants is a lack of melanocytes within the stria vascularis (SV) associated with an endocochlear potential (EP) close to zero and hearing impairment. In this study, we compare inner ear pigmentation with cochlear potentials in three...

Topics

Action Potentials
Alleles
Animals
Cell Movement
Chimera
Cochlear Microphonic Potentials
Dog Diseases
Dogs
Ear, External
Fetal Tissue Transplantation
Hair Color
Hearing Loss, Sensorineural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Melanocytes

Mice

Mice, Inbred C3H

Mice, Inbred C57BL

Mice, Inbred CBA

Source

Open in PubMed

Identifiers

PMID: 7521050
DOI: 10.1111/j.1600-0749.1994.tb00015.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7521050-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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