Article

Meiotic resetting of the cellular Sod1 pool is driven by protein aggregation, degradation, and transient LUTI-mediated repression

2022-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Gametogenesis requires packaging of the cellular components needed for the next generation. In budding yeast, this process includes degradation of many mitotically stable proteins, followed by their resynthesis. Here, we show that one such case—Superoxide dismutase 1 (Sod1), a protein that commonly aggregates in human ALS patients—is regulated by an integrated set of events, beginning with the f...

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Literature Corpus work: 22f79e5d-5b40-55b8-9a19-22724dc14264
DOI: 10.1101/2022.06.28.498006

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