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Article

Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria.

The Journal of biological chemistry - 25 Jul 2003

Field Lori Sturtz, Furukawa Yoshiaki, O'Halloran Thomas V, Culotta Valeria Cizewski

Abstract excerpt

We have previously shown that a fraction of yeast copper/zinc-superoxide dismutase (SOD1) and its copper chaperone CCS localize to the intermembrane space of mitochondria. In the present study, we have focused on the mechanism by which SOD1 is partitioned between cytosolic and mitochondrial pools. Using in vitro mitochondrial import assays, we show that only a very immature form of the SOD1 polypeptide that is...

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Source

Identifiers

PMID: 12748182
DOI: 10.1074/jbc.M304296200

Genes

SOD1
CCS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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