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Article

SOD1 oxidation and formation of soluble aggregates in yeast: relevance to sporadic ALS development.

Redox biology - 1 Jan 2014

Martins Dorival, English Ann M

Abstract excerpt

Misfolding and aggregation of copper-zinc superoxide dismutase (Sod1) are observed in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Mutations in Sod1 lead to familial ALS (FALS), which is a late-onset disease. Since oxidative damage to proteins increases with age, it had been proposed that oxidation of Sod1 mutants may trigger their misfolding and aggregation in FALS. However, over 90%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Source

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Identifiers

PMID: 24936435
DOI: 10.1016/j.redox.2014.03.005
PMCID: PMC4052529

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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