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The journey of developing hematopoietic stem cells

12 Sept 2006

Abstract excerpt

Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that involves multiple anatomical sites. Once HSC precursors have been specified from mesoderm, they have to mature into functional HSCs and undergo self-renewing divisions to generate a pool of HSCs. During this process, developing HSCs migrate through various embryonic niches, which provide signals for their establishment and the...

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PMID: 16968814
DOI: 10.1242/dev.02568

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