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Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

31 Oct 2011

Abstract excerpt

Hematopoietic stem cells (HSCs) emerge during embryogenesis and maintain hematopoiesis in the adult organism. Little is known about the embryonic development of human HSCs. We demonstrate that human HSCs emerge first in the aorta-gonad-mesonephros (AGM) region, specifically in the dorsal aorta, and only later appear in the yolk sac, liver, and placenta. AGM region cells transplanted into immunodeficient mice...

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PMID: 22042975
DOI: 10.1084/jem.20111688

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