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Targeting the SUMO pathway primes all- <i>trans</i> -retinoic acid-induced differentiation of non promyelocytic Acute Myeloid Leukemias

2018-01-29

Abstract excerpt

Differentiation therapies using All- trans -retinoic acid (ATRA) are highly efficient at treating Acute Promyelocytic Leukemia (APL), a minor subtype of Acute Myeloid Leukemias (AML). However, their efficacy, if any, is very limited in the case of non-APL AMLs. We report here that the inhibition of SUMOylation, a post-translational modification related to ubiquitinylation, restores the pro-differentiation and ant...

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Literature Corpus work
22cfd224-ac08-5427-b5f0-450ec59ad6e3
DOI
10.1101/254946
Open publication

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