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Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies

18 Mar 2013

Abstract excerpt

In PML/RARA-driven acute promyelocytic leukemia (APL), retinoic acid (RA) induces leukemia cell differentiation and transiently clears the disease. Molecularly, RA activates PML/RARA-dependent transcription and also initiates its proteasome-mediated degradation. In contrast, arsenic, the other potent anti-APL therapy, only induces PML/RARA degradation by specifically targeting its PML moiety. The respective...

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PMID: 23509325
DOI: 10.1084/jem.20122337

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