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Article

Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products

8 Feb 2020

Abstract excerpt

Thrombin-derived C-terminal peptides (TCPs), including a major 11-kDa fragment (TCP96), are produced through cleavage by human neutrophil elastase and aggregate lipopolysaccharide (LPS) and the Gram-negative bacterium Escherichia coli . However, the physiological roles of TCP96 in controlling bacterial infections and reducing LPS-induced inflammation are unclear. Here, using various biophysical methods, in silico...

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PMID: 32034093
DOI: 10.1074/jbc.ra120.012741

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