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Porphyromonas gingivalis protease Rgp induces M1-type polarization and pyroptosis in BV-2 cells by inhibiting SIRT1 expression

2024-06-04

Abstract excerpt

<title>Abstract</title> <p>Background Periodontitis and Alzheimer's disease (AD) are age-related diseases that reciprocally act as risk factors. It has been reported that periodontal pathogen <italic>Porphyromonas gingivalis</italic> and its gingipains contribute to neuroinflammation mediated by microglial cells, playing a crucial role in the onset of AD. However, it remains unclear whether gingipains play a pro...

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Literature Corpus work
1095a25d-3394-5501-8231-cf0effd0c11e
DOI
10.21203/rs.3.rs-4448326/v1
Open publication

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