Article

Material-Driven Fibronectin Assembly Rescues Matrix Defects due to Mutations in Collagen IV in Fibroblasts

2020-01-06

Abstract excerpt

Basement membranes (BMs) provide structural support to tissues and influence cell signaling. Mutations in COL4A1/COL4A2, a major BM component, cause eye, kidney and cerebrovascular disease, including stroke. Common variants in these genes are risk factors for intracerebral hemorrhage in the general population. However, the contribution of the matrix to the disease mechanism(s) and its effects on the biology of cel...

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Literature Corpus work: 22b3af2d-4454-5292-b4aa-4f42e4dcf60a
DOI: 10.1101/2020.01.06.895839

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