Article

Nanoscale Structural and Functional Impacts of Disease-Associated Collagen Mutations

2025-09-04

Abstract excerpt

Collagen is the most abundant structural protein in the human body, and its supramolecular organization is central to tissue mechanics and cell–matrix interactions. Integrins, key mediators of these interactions, are essential for key biological processes including adhesion, migration, differentiation, and platelet aggregation. While mutations in collagen are known to cause connective tissue disorders such as Oste...

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Literature Corpus work: 693e5537-6a51-5204-a22f-fefa9b6aa1c9
DOI: 10.1101/2025.09.03.673992

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