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Article

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

The Journal of biological chemistry - 15 Jan 2016

Pilecki Bartosz, Holm Anne T, Schlosser Anders, Moeller Jesper B, Wohl Alexander P, Zuk Alexandra V, Heumüller Stefanie E, Wallis Russell, Moestrup Soren K, Sengle Gerhard, Holmskov Uffe, Sorensen Grith L

Abstract excerpt

MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role in elastic fiber assembly. In the present study, we characterized molecular interactions between MFAP4 and elastic fiber components. We established that MFAP4 primarily assembles into trimeric and hexameric structures of homodimers. Binding analysis revealed that MFAP4 specifically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26601954
DOI: 10.1074/jbc.M115.681775
PMCID: PMC4714194

Genes

MFAP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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