Article

Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells

2023-09-22

Abstract excerpt

Microfibrillar-associated protein 4 (MFAP4) is a 36-kDa extracellular glycoprotein with critical roles in human pathologies, including fibrosis in several organ systems, chronic obstructive pulmonary disease, and cardiovascular disorders. In elastic tissues such as arteries, lungs, and skin, MFAP4 associates with microfibrils and elastic fibres, which are the central extracellular fibres affected in thoracic aneur...

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Literature Corpus work: fca01596-6fb3-55df-b01c-fdbb19d7c4ca
DOI: 10.1101/2023.09.22.558839

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