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Laminin Polymerization and Inherited Disease: Lessons From Genetics

12 Aug 2021

Abstract excerpt

The laminins (LM) are a family of basement membranes glycoproteins with essential structural roles in supporting epithelia, endothelia, nerves and muscle adhesion, and signaling roles in regulating cell migration, proliferation, stem cell maintenance and differentiation. Laminins are obligate heterotrimers comprised of α, β and γ chains that assemble intracellularly. However, extracellularly these heterotrimers...

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PMID: 34456976
DOI: 10.3389/fgene.2021.707087

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