Polymerizing laminins in development, health, and disease.

Abstract excerpt

Polymerizing laminins are multi-domain basement membrane (BM) glycoproteins that self-assemble into cell-anchored planar lattices to establish the initial BM scaffold. Nidogens, collagen-IV and proteoglycans then bind to the scaffold at different domain loci to create a mature BM. The LN domains of adjacent laminins bind to each other to form a polymer node, while the LG domains attach to cytoskeletal-anchoring...

Topics

• Humans
• Laminin
• Animals
• Basement Membrane
• Muscular Dystrophies
• Limb Deformities, Congenital
• Mutation
• Nephrotic Syndrome
• Pupil Disorders
• Myasthenic Syndromes, Congenital