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Article

Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts.

Biomaterials - 1 Sept 2020

Ngandu Mpoyi Elie, Cantini Marco, Sin Yuan Yan, Fleming Lauren, Zhou Dennis W, Costell Mercedes, Lu Yinhui, Kadler Karl, García Andrés J, Van Agtmael Tom, Salmeron-Sanchez Manuel

Abstract excerpt

Basement membranes (BMs) are specialised extracellular matrices that provide structural support to tissues as well as influence cell behaviour and signalling. Mutations in COL4A1/COL4A2, a major BM component, cause a familial form of eye, kidney and cerebrovascular disease, including stroke, while common variants in these genes are a risk factor for intracerebral haemorrhage in the general population. These...

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Identifiers

PMID: 32413593
DOI: 10.1016/j.biomaterials.2020.120090
PMCID: PMC8822498

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