Article

KAT3 mutations impair neural crest migration through EMT regulators <i>snai1b a</i> nd <i>snai2</i> in Rubinstein Taybi Syndrome

2024-05-19

Abstract excerpt

Rubinstein Taybi syndrome, a rare congenital disease is caused by mutation in KAT3 genes, EP300 and CREBBP . A subset of tissues affected in RSTS have their origin in neural crest cells, prompting our exploration into the role of KAT3 in neural crest development. Our zebrafish RSTS models generated by knocking down or mutating ep300a and cbpa genes, reveal defects in neural crest migration and its derived tiss...

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Literature Corpus work: b562368d-d84e-5854-9178-b9ea10815f1c
DOI: 10.1101/2024.05.19.593474

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