Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.

Developmental biology - 15 Dec 2008

Gaston-Massuet Carles, Andoniadou Cynthia L, Signore Massimo, Sajedi Ezat, Bird Sophie, Turner James M A, Martinez-Barbera Juan Pedro

Abstract excerpt

Hesx1 has been shown to be essential for normal pituitary development. The homeobox gene Six3 is expressed in the developing pituitary gland during mouse development but its function in this tissue has been precluded by the fact that in the Six3-deficient embryos the pituitary gland is not induced. To gain insights into the function of Six3 during pituitary development we have generated Six3+/- ;Hesx1Cre/+ double...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dwarfism, Pituitary
Share to Eye Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Homeobox

Share to Gonads

Share to Homeodomain Proteins

Share to Pituitary Gland, Anterior

Share to Repressor Proteins

Share to Thyroid Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 18775421
DOI: 10.1016/j.ydbio.2008.08.008
PMCID: PMC3606136

Genes

SIX3
HESX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.PMID 18775421Read ↗

Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man.Semantic proximity Read ↗

Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly.Semantic proximity Read ↗

SOX3 is required during the formation of the hypothalamo-pituitary axis.Semantic proximity Read ↗

Genetic Regulation of Pituitary Gland Development in Human and MouseSemantic proximity Read ↗

The molecular basis for developmental disorders of the pituitary gland in manSemantic proximity Read ↗

Developmental disorders of the hypothalamus and pituitary gland associated with congenital hypopituitarism.Semantic proximity Read ↗

Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial DevelopmentSemantic proximity Read ↗

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.Semantic proximity Read ↗

Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary DevelopmentSemantic proximity Read ↗

Hypothalamic and pituitary development: novel insights into the aetiology.Semantic proximity Read ↗

A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction.Semantic proximity Read ↗

Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.