Article

CRISPR Cas9 Mediated Generation of Bex2 KO Mouse Model and Transcriptome Analysis of the Brain

2022-02-03

Abstract excerpt

<h4>Background: </h4> BEX family genes are expressed in many tissues and play significant roles in neuronal development. <h4>Methods: </h4>. In this study, a mouse model of Bex2 gene knockout was generated, using the CRISPR-Cas9 system. A fragment of the coding exon was successfully deleted. RT-qPCR confirmed loss of gene expression at the mRNA level. A transcriptomic study of the brain was performed to identify...

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Literature Corpus work: 7d0e0b5d-0d1b-57ae-856b-41400200586c
DOI: 10.21203/rs.3.rs-1255516/v1

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