Article

Direct Plasmonic Detection of Circulating RAS Mutated DNA in Colorectal Cancer Patients

2020-07-09

Abstract excerpt

By exploiting a liquid biopsy approach, we developed an ultrasensitive nanoparticle-enhanced plasmonic method for detecting RAS single nucleotide variants (SNVs) in the plasma of CRC patients. The PCR-free method we developed is based on an imaging platform and allows the direct detection of ~1 attomolar RAS sequences in plasma with a sandwich hybridization assay using peptide nucleic acids probes. The assay invol...

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Literature Corpus work: 229fd29f-d9f4-551d-ad5d-9b9625443adb
DOI: 10.26434/chemrxiv.12625439.v1

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