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Article

Ultraspecific Multiplexed Detection of Low-Abundance Single-Nucleotide Variants by Combining a Masking Tactic with Fluorescent Nanoparticle Counting.

Analytical chemistry - 20 Mar 2018

Pei Xiaojing, Lai Tiancheng, Tao Guangyu, Hong Hu, Liu Feng, Li Na

Abstract excerpt

To be able to detect simultaneously multiple single-nucleotide variants (SNVs) with both ultrahigh specificity and low-abundance sensitivity is of pivotal importance for molecular diagnostics and biological research. In this contribution, we for the first time developed a multiplex SNV detection method that combines the masking tactic with fluorescent nanoparticle (FNP) counting based on the sandwich design. The...

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PMID: 29504392
DOI: 10.1021/acs.analchem.8b00685

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KRAS

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