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Direct plasmonic detection of circulating RAS mutated DNA in colorectal cancer patients.

Biosensors & bioelectronics - 15 Dec 2020

D'Agata Roberta, Bellassai Noemi, Allegretti Matteo, Rozzi Andrea, Korom Saša, Manicardi Alex, Melucci Elisa, Pescarmona Edoardo, Corradini Roberto, Giacomini Patrizio, Spoto Giuseppe

Abstract excerpt

RAS mutations in the blood of colorectal cancer (CRC) patients are emerging as biomarkers of acquired resistance to Epidermal Growth Factor Receptor therapy. Unfortunately, reliable assays granting fast, real-time monitoring of treatment response, capable of refining retrospective, tissue-based analysis, are still needed. Recently, several methods for detecting blood RAS mutations have been proposed, generally...

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PMID: 33010708
DOI: 10.1016/j.bios.2020.112648

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