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Article

Rapid KRAS Mutation Detection via Hybridization-Induced Aggregation of Microbeads.

Analytical chemistry - 20 Oct 2015

Sloane Hillary S, Kelly Kimberly A, Landers James P

Abstract excerpt

Using hybridization-induced aggregation (HIA), a unique bead-based DNA detection technology scalable for a microchip platform, we describe a simplistic, low-cost method for rapid mutation testing. HIA utilizes a pair of sequence-specific oligonucleotide probes bound to magnetic microbeads. Hybridization to a target DNA strand tethers the beads together, inducing bead aggregation. By simply using the extent of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26339780
DOI: 10.1021/acs.analchem.5b01876

Genes

KRAS

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