Article

PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling

2025-08-23

Abstract excerpt

<h4>Summary</h4> Identifying drivers of metastasis is essential for developing new treatments for patients with advanced disease. Here, we identify PHLDA2 as a robust driver of breast cancer metastasis. Previous work established PHLDA2 as an imprinted gene expressed by trophoblasts which are critical for vascular remodeling during placental development. We find that hypomethylation of PHLDA2 in breast tumors c...

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Identifiers and source

Literature Corpus work: 229612bd-5b77-5c74-a274-1f1dc2d1bd44
DOI: 10.1101/2025.08.19.670946

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