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Article

Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays

18 Jul 2008

Abstract excerpt

INTRODUCTION: Breast cancer metastasis is a complex, multi-step biological process. Genetic mutations along with epigenetic alterations in the form of DNA methylation patterns and histone modifications contribute to metastasis-related gene expression changes and genomic instability. So far, these epigenetic contributions to breast cancer metastasis have not been well characterized, and there is only a limited...

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PMID: 18638373
DOI: 10.1186/bcr2121

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