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MYBL2 amplification in breast cancer: Molecular mechanisms and therapeutic potential.

Biochimica et biophysica acta. Reviews on cancer - 1 Dec 2020

Bayley Rachel, Ward Ciara, Garcia Paloma

Abstract excerpt

The MYBL2 gene, also known as B-MYB, is essential to regulate vital cellular processes including cell proliferation, differentiation and DNA repair. Changes in these pathways can facilitate cancer development and as such targeting these processes represent an effective method to treat multiple cancer types. Alterations in gene expression have been identified in cancer cells including changes in MYBL2, which...

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Gene Amplification
Biomarkers, Tumor
Breast Neoplasms
Cell Cycle Proteins
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Survival Analysis

Trans-Activators

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PMID: 32853735
DOI: 10.1016/j.bbcan.2020.188407

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