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Article

Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.

Nature structural & molecular biology - 1 Nov 2023

Nakamura Toshitaka, Mishima Eikan, Yamada Naoya, Mourão André Santos Dias, Trümbach Dietrich, Doll Sebastian, Wanninger Jonas, Lytton Elena, Sennhenn Peter, Nishida Xavier da Silva Thamara, Angeli José Pedro Friedmann, Sattler Michael, Proneth Bettina, Conrad Marcus

Abstract excerpt

Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for the treatment of cancers. Ferroptosis suppressor protein-1 (FSP1), as the second ferroptosis mainstay, efficiently prevents lipid peroxidation via NAD(P)H-dependent reduction of quinones. Because its molecular mechanisms have remained obscure, we studied numerous FSP1 mutations present in cancer or identified by untargeted...

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PMID: 37957306
DOI: 10.1038/s41594-023-01136-y
PMCID: PMC10643123

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