Article

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukaemia

2024-08-12

Abstract excerpt

The ubiquitous metabolite heme has diverse enzymatic and signalling functions in most mammalian cells. Cells can salvage heme from the extracellular environment or synthesise heme de novo from succinyl-CoA and glycine through a series of 8 enzymatic reactions catalysed by heme biosynthesis enzymes (HBEs) localised in the mitochondria and the cytosol 1,2 . Through integrated analyses of mouse models, human cell l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd1b6b9d-d896-5b19-8926-25f24ea23425
DOI: 10.1101/2024.08.11.607520

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukaemiaDOI 10.1101/2024.08.11.607520Read

Heme-Sensing Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-MimeticsSemantic proximity Read

Porphyrin overdrive rewires pan-cancer cell metabolismSemantic proximity Read

IDH1 mutation creates a dependency on fatty acid metabolism that underlies sensitivity to cuproptosis in acute myeloid leukemia cells.Semantic proximity Read

Porphyrin overdrive rewires cancer cell metabolismSemantic proximity Read

Cuproptosis-related genes and agents: implications in tumor drug resistance and future perspectivesSemantic proximity Read

SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.Semantic proximity Read

Congenital sideroblastic anemia: Unravelling molecular pathogenesis and advancing precision therapeutics.Semantic proximity Read

Acute hepatic and erythropoietic porphyrias: from ALA synthases 1 and 2 to new molecular bases and treatments.Semantic proximity Read

Mitochondrial abnormalities as a target of intervention in acute myeloid leukemiaSemantic proximity Read

Susceptibility of acute myeloid leukemia cells to ferroptosis and evasion strategiesSemantic proximity Read

Genome-wide CRISPR screens identify ferroptosis as a novel therapeutic vulnerability in acute lymphoblastic leukemiaSemantic proximity Read

Chromatin regulator perturbation causes heme pathway imbalance in yeast and human cellsSemantic proximity Read