Article
Epigenetic Modifications and Their Role in Type 1 Diabetes Development: A Review.
Current diabetes reviews - 1 Jan 2026
de Azevedo Jenner Chrystian Veríssimo, Fernandes Fernando Liberalino, Rodrigues Tayline Dantas, de Medeiros Iluska Almeida Carneiro Martins, Andrade Vania Sousa, de Araujo Joselio Maria Galvao, Bezerra Fabiana Lima, Bezerra Christiane Medeiros, de Medeiros Fernandes Thales Allyrio Araujo, Fernandes José Veríssimo
Abstract excerpt
INTRODUCTION: Type 1 Diabetes Mellitus (T1DM) is a multifactorial autoimmune disease marked by pancreatic β-cell destruction and insulin deficiency. Its pathogenesis involves genetic predisposition, environmental exposures, and epigenetic modifications. This review examines how epigenetic mechanisms, including DNA methylation, histone modifications, and noncoding RNAs, contribute to T1DM and their potential as...
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