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Article

Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.

International journal of molecular sciences - 20 Jan 2023

Kim Meewhi, Bezprozvanny Ilya

Abstract excerpt

Proteolytic processing of amyloid precursor protein (APP) plays a critical role in pathogenesis of Azheimer's disease (AD). Sequential cleavage of APP by β- and γ-secretases leads to generation of Aβ40 (non-amyloidogenic) and Aβ42 (amyloidogenic) peptides. Presenilin-1 (PS1) or presenilin-2 (PS2) act as catalytic subunits of γ-secretase. Multiple familial AD (FAD) mutations in APP, PS1, or PS2 affect APP...

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Identifiers

PMID: 36768421
DOI: 10.3390/ijms24032092
PMCID: PMC9916408

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